CuraGen Corporation

CuraGen Corporation is listed on NASDAQ (CRGN). The following Business Section contains forward-looking statements, which involve risks and uncertainties. The registrant's actual results could differ materially from those anticipated in these forward-looking statements as a result of certain factors. See also Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations-Risk Factors. BUSINESS Overview We are a genomics-based pharmaceutical development company dedicated to improving the lives of patients by developing novel protein, antibody and small molecule therapeutics in the areas of oncology, inflammatory diseases, and diabetes. We have taken a systematic approach to identifying and validating the most promising therapeutic targets from the human genome. We use internal resources to develop our potential protein therapeutics and have established development alliances with Abgenix, Inc.

Curis Inc.

Curis Inc. is listed on NASDAQ (CRIS). We are a therapeutic drug development company principally focused on the discovery, development and future commercialization of products that modulate key regulatory signaling pathways controlling the repair and regeneration of human tissues and organs. Our product development approach involves using small molecules, proteins or antibodies to modulate these regulatory signaling pathways, for example, to increase the pathway signals when they are insufficient or to decrease them when they are excessive. Our lead product candidate is a topical therapy for the treatment of basal cell carcinoma and is currently under development with Genentech, Inc., a collaborator. Under the terms of our collaboration with Genentech, we retained a co-development option in the basal cell carcinoma program in the U.S. market pursuant to which we will share in the U.S. development costs and any future U.S. net profits and-or losses in this program.

Edwards Lifesciences Corporation ..thin the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. The Company intends the forward-..

99 CENTS ONLY STORES ..nsumable general merchandise with an emphasis on name-brand products. The Companys stores offer a wide assortment of regularly available consumer good..

Embrex Inc. ..ural biotechnology company engaged in the development of innovative in ovo (in the egg) solutions that meet the needs of the global poultry industry. ..

eOn Communications Corporation ..elops and markets unified voice, email and Web-based communications systems and software for customer contact centers and general business application..

Everlast Worldwide Inc. .. constitute forward-looking statements within the meaning of Section 27A of the Securities Act and Sections 21E of the Exchange Act. Such forward-look..

Liberte Investors Inc. ..s) is a retailer, servicer and underwriter of non-standard personal automobile insurance based in Nashville, Tennessee. We currently write non-standar..

FirstBank NW Corp. ..organized in Delaware in March 1997 to become the holding company for FirstBank Northwest (formerly known as First Federal Bank of Idaho, a Federal Sa..

Feldman Mall Properties Inc. ..d, self-administered and self-managed real estate company formed in July 2004 to continue the business of Feldman Equities of Arizona to acquire, reno..

Fairfax Financial Holdings Ltd ..inancial services holding company which, through its subsidiaries, is engaged in property and casualty insurance and reinsurance, investment managemen..

Leesport Financial Corporation .. headquartered at 1240 Broadcasting Road, Wyomissing, Pennsylvania 19610. The Company was organized as a bank holding company on January 1, 1986. The ..

FoxHollow Technologies Inc. ..evices primarily for the treatment of peripheral artery disease. PAD results from the accumulation of plaque in arteries, most commonly occurring in t..

Franklin Street Properties Corp. ..ch we will refer to as FSP Corp. or the Company, is a Maryland corporation that operates in a manner intended to qualify as a real estate investment t..

Flotek Industries Inc. ..porated under the laws of the Province of British Columbia on May 17, 1985. On October 23, 2001, we approved a change in our corporate domicile to the..

Gladstone Investment Corporation ..ted under the General Corporation Laws of the State of Delaware on February 18, 2005. On June 22, 2005 we completed an initial public offering and com..

Grill Concepts Inc. ..t otherwise requires, as used herein, the Company, we, our, or us, means Grill Concepts, Inc., a Delaware corporation and its subsidiaries. GENERAL Gr..

Glen Burnie Bancorp ..anized in 1990 under the laws of the State of Maryland. It presently owns all the outstanding shares of capital stock of The Bank of Glen Burnie, a co..

GoAmerica Inc. ..vice provider, offering solutions primarily for consumers who are deaf, hard of hearing and-or speech-impaired, including wireless subscription and va..

Genco Shipping & Trading Limited .. in the Marshall Islands. We transport iron ore, coal, grain, steel products and other drybulk cargoes along worldwide shipping routes. Our fleet cons..

Granite Construction Incorporated .. Construction Company. In 1990, Granite Construction Incorporated was incorporated in Delaware as the holding company for Granite Construction Company..

Hampshire Group Limited ..ware corporation, is a holding company that markets apparel through two wholly-owned subsidiaries, Hampshire Designers, Inc. (Hampshire Designers) and..

Healthcare Technologies Ltd. ..liability company under the law of the state of Israel in May 1988. The Company's principal executive offices are located at Beit Amargad, 32 Shaham S..

Harolds Stores Inc. ..ries, through a chain of ladies and mens specialty apparel stores in 19 states, offers high-quality, classically inspired apparel to the upscale, qual..

Hutchinson Technology Incorporated ..an Hutchinson Technology Incorporated and its subsidiaries. Unless otherwise indicated, references to 2006 mean our fiscal year ending September 24, 2..

Hutchison Telecommunications International Limited ..rovider of mobile and fixed-line telecommunications services. We currently serve eight markets around the world: Hong Kong, Macau, India, Israel, Thai..

International Assets Holding Corporation ..ubsidiaries form a financial services group focused on select international markets. We commit our capital and expertise to market-making and trading..

Icagen Inc. ..discovery, development and commercialization of novel orally-administered small molecule drugs that modulate ion channel targets. Ions are charged par..

INFINEON TECHNOLOGIES AG ..cal Year The business name of the company is Infineon Technologies AG. º (2) º The companys registered place of business is Munich. º (3) º The fiscal..

I-many Inc. ..oking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, ..

World Fuel Services Corporation ..in Florida in July 1984 and along with its consolidated subsidiaries is referred to collectively in this Annual Report on Form 10-K as World Fuel, we,..

Insignia Systems Inc. ..ing products, programs and services to retailers and consumer packaged goods manufacturers. The Company has been in business since 1990. Since 1998, t..

ITC Holdings Corp. ..ber 2002 for the purpose of acquiring Predecessor ITCTransmission. ITC Holdings is a holding company with no business operations and its material asse..

Invitrogen Corporation .. 1987 and incorporated in California in 1989. In 1997 we reincorporated as a Delaware corporation. Our principal offices are in Carlsbad, California. ..

JOHNSON & JOHNSON .. people worldwide, is engaged in the manufacture and sale of a broad range of products in the health care field. Johnson & Johnson has over 200 subsid..

Key Technology Inc. ..r of vegetable processing equipment. The Company has evolved into a worldwide supplier of process automation solutions to the food processing industry..

Carmike Cinemas Inc. ..s in the United States. As of December 31, 2004, we owned, operated or had an interest in 282 theatres with 2,188 screens located in 36 states, making..

K-Tron International Inc. ..tion founded in 1964, and our Common Stock trades on the Nasdaq National Market under the symbol KTII. We are engaged in one principal business segmen..

Lakeland Bancorp Inc. .. is a bank holding company registered with and supervised by the Board of Governors of the Federal Reserve System (the Federal Reserve Board). The Com..

Lehman Brothers Fin SA ..ehman Brothers Holdings Inc., a Delaware corporation, incorporated on December 29, 1983. Holdings and its subsidiaries are collectively referred to as..

LMI Aerospace Inc. ..achining, finishing and integrating formed, close tolerance aluminum and specialty alloy components and sheet metal products for use by the aerospace,..

Leucadia National Corporation ..ed in a variety of businesses, including telecommunications, healthcare services, manufacturing, banking and lending, real estate activities, winery o..

MACC Private Equities Inc. ..e corporation on March 3, 1994. It is qualified as a business development company (BDC) under the Investment Company Act of 1940, as amended (the 1940..

McDermott International Inc. ..ed under the laws of the Republic of Panama in 1959 and is the parent company of the McDermott group of companies, which includes: . J. Ray McDermott,..

MEDICURE INC ..ertificate of Incorporation issued pursuant to the provisions of the Business Corporations Act (Alberta) on June 3, 1997. On February 11, 1999, by Cer..

Allstate Corporation (The) ..e laws of the State of Delaware on November 5, 1992 to serve as the holding company for Allstate Insurance Company. Its business is conducted principa..

Multimedia Games Inc. ..electronic games, and gaming terminals for the Native American gaming market, as well as for the growing racetrack casino, charity and commercial bing..

MIVA Inc. ..providing e-commerce solutions since 1998. We offer proprietary performance-based marketing and commerce enabling services that help businesses of all..

Modine Manufacturing Company ..chnology, serving the vehicular, industrial, commercial, electronic and building HVAC (heating, ventilating, and air conditioning) markets. Modine dev..

Marvell Technology Group Ltd. ..high-performance analog, mixed-signal, digital signal processing and embedded microprocessor integrated circuits. Our diverse product portfolio includ..

Mitcham Industries Inc. ..s incorporated in 1987. Since our organization, we have primarily been engaged in the leasing and sales of seismic equipment to the seismic industry w..

MITY Enterprises Inc. ..markets premium quality, innovative institutional furniture created to meet the efficiency needs of its customers. The Companys product lines include ..

Nabors Industries Inc. ..the world, with almost 600 land drilling rigs. We conduct oil, gas and geothermal land drilling operations in the U.S. Lower 48 states, Alaska, Canada..

Nordson Corporation ..producers of precision dispensing equipment that applies adhesives, sealants and coatings to a broad range of consumer and industrial products during ..

National Home Health Care Corp. ..poration that is a provider of home health care and staffing services in the Northeast region. INDUSTRY OVERVIEW United States health care spending co..

Numerex Corp. ..achine-to-machine (M2M) communications, delivering comprehensive wireless solutions over the company's proprietary wireless data network, CellemetryXG..

North Valley Bancorp ..0-K (excluding statements of fact or historical financial information) involve forward-looking information within the meaning of Section 27A of the Se..

Northern States Power Co Minnesota ..wned five utility subsidiaries that serve electric and natural gas customers in 11 states. Four of these utility subsidiaries are SEC registrants, inc..

Naugatuck Valley Financial Corporation ..he capital we raised in our 2004 stock offering may negatively impact our stock price. Return on equity, which equals net income divided by average eq..

New York Community Bancorp Inc. ..mpany for New York Community Bank and the fourth largest thrift in the nation, with assets of $24.0 billion at December 31, 2004. The Bank is the lead..

Omega Flex Inc. ..TS Certain statements in this Annual Report on Form 10-K that are not historical facts - but rather reflect our current expectations concerning future..

ONYX Software Corporation ..rovider of enterprise solutions that combine customer management, process management and performance management technologies to help organizations mor..

Orange 21 Inc. ..ooking statements that involve a number of risks and uncertainties. These forward-looking statements include, but are not limited to, statements and p..

Pioneer Natural Resources Company ..ck is listed and traded on the NYSE. The Company is a large independent oil and gas exploration and production company with operations in the United S..

Playboy Enterprises Inc. ..diaries and predecessors, will be referred to in this Form 10-K Annual Report by terms such as we, us, our, Playboy and the Company, unless the contex..

Provident Financial Services ..nuary 15, 2003, became the holding company for The Provident Bank, following the completion of the conversion of the Bank to a stock chartered savings..

Papa Johns International Inc. ..hises pizza delivery and carryout restaurants under the trademark Papa John's. At December 26, 2004, the Company and its franchisees operated domestic..

Regions Financing Tr I ..ubsidiaries on a consolidated basis, Regions or Company), is a financial holding company headquartered in Birmingham, Alabama which operates primarily..

RADVision Ltd. ..f Israel in January1992, commenced operations in October 1992 and commenced sales of our products in the fourth quarter of 1994. Before that time, our..

Sea Containers Ltd. ..h its subsidiaries, SCL) is incorporated in the Islands of Bermuda and is a foreign private issuer as defined in Rule 3b-4 of the U.S. Securities and ..

SiRF Technology Holdings Inc. ..stem, or GPS, semiconductor solutions designed to provide location awareness capabilities in high-volume mobile consumer and commercial applications. ..

Spectrum Pharmaceuticals Inc. ..ration that was originally incorporated in Colorado as Americus Funding Corporation in December 1987, became NeoTherapeutics, Inc. in August 1996, was..

Specialty Underwriters Alliance Inc. ..ly-owned subsidiary, SUA Insurance Company, offer commercial property and casualty insurance to selected customer groups. We believe that we are diffe..

Tele Norte Leste Participacoes S.A. .. telecommunications services in South America based on the total number of lines in service, which we market under our Telemar brand name. 15 - Table ..

Trend Micro Incorporated ..velop, market and support antivirus and Internet content security software and services. Our legal name in Japan is Trend Micro Kabushiki Kaisha and T..